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Rockefeller University Research Support Specialist, High Throughput Screening Resource Center in New York, New York

Job: IRC26045


Job Title Research Support Specialist, High Throughput Screening Resource Center

Laboratory / Department High Throughput Screening Resource Center

Department Description

The High-Throughput and Spectroscopy Resource Center (HTSRC) supports scientists in the screening and identification of compounds and genetic modulators of in vitro assays which utilize optical and other bio-analytical technologies. High-Throughput Screening (HTS) requires the miniaturization and automation of bioassays so that millions of variables can be tested. HTS is often an important step in the discovery of new medicines. The center has a collection of over 380,000 compounds, automated liquid transfer devices, compound databases, and supports a broad diversity of assay development techniques, typically found in early drug discovery programs. The Center is configured for processing 96, 384 and 1536-well microtiter plates through the use of automated changeable tip dispensers, non-contact dispensers, and syringe dispensers. For assay technologies, the HTSRC has the capability to support cellular and biochemical assays using absorbance, fluorescent kinetics, fluorescence anisotropy, time-resolved fluorescence, time-resolved fluorescence resonance energy transfer, AlphaScreen, bioluminescence, for example luciferase and green fluorescent protein, scintillation proximity and cellular fluorescence imaging. Assay targets can include ion channels, receptors, enzymes, protein interactions, signaling pathways and cellular processes.

The High-Throughput and Spectroscopy Resource Center also oversees the management of, training for, and scheduling for optical spectroscopic and calorimetric equipment for use in studies of the structure, function and interactions of biological and organic molecules. This includes an on-campus facility for nuclear magnetic resonance spectroscopy with priority access given to University researchers. The Center offers extensive training in basic and advanced NMR experiments and also coordinates access to high field spectrometers (700, 800, and 900 MHz) at the New York Structural Biology Center through the University's partnership in that Center. HTSRC staff provides general background training in applications of NMR spectroscopy to structural biology and chemistry and hands on training on the spectrometers. Trained users have 24/7 access to these instruments. Occasional users of the facilities may have spectra produced for them.

Detailed Description

The Research Support Specialist will join the High Throughput and Spectroscopy Resource Center (HTSRC) and assist in guiding our faculty and students in improving the efficiency of their bioassays, identifying compounds and genetic modulators of function, and implementing novel technologies applied to the analysis of molecular recognition. The Research Support Specialist will be responsible for developing and conducting biochemical, cell-based, and biophysical assays and high throughput screens (HTS). Will train technicians, graduate students, and postdocs in the technical implementation of spectroscopy, tool, and drug discovery projects, pipetting, design of HTS experiments, and use of instruments. The Research Support Specialist will evaluate new technologies and approaches for HTS and spectroscopy, as well as contribute to the writing of scientific manuscripts and composition of methods, figures, and figure legends for published materials. Responsibilities will also include procuring necessary repairs, and maintaining and independently troubleshooting equipment, including microplate readers, high-throughput microscopes, spectroscopic instruments, and automated liquid dispensers.

Job Requirements

Ph.D. required; educational emphasis in biochemistry, cell biology, molecular biology, or chemical biology preferred. Experience working with users in the design of HTS experiments and the use of instruments preferred. Must be skilled in data organization, analysis, entry and interpretation. Excellent communication and customer service skills required.

Additional Details

The Rockefeller University is an Equal Opportunity Employer - Minorities/Women/Disabled/Veterans